Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring

Folate is an essential vitamin for vertebrate embryo development. Methotrexate (MTX) is a folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ malignancies, and dermatologic diseases. Although it is highly contraindicated for pregnant women, because it is associ...

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Detalles Bibliográficos
Autores principales: Alata Jimenez, Nagif, Castellano, Mauricio, Santillan, Emilio M., Boulias, Konstantinos, Boan, Agustín, Arias Padilla, Luisa F., Fernandino, Juan I., Greer, Eric L., Tosar, Juan P., Cochella, Luisa, Strobl-Mazzulla, Pablo H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036556/
https://www.ncbi.nlm.nih.gov/pubmed/36959185
http://dx.doi.org/10.1038/s41467-023-37427-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036556/
https://www.ncbi.nlm.nih.gov/pubmed/36959185
http://dx.doi.org/10.1038/s41467-023-37427-7

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