Antigen discrimination by T cells relies on size-constrained microvillar contact

T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a target cell’s glycocalyx. Here, T cells are observed to use microvilli to b...

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Detalles Bibliográficos
Autores principales: Jenkins, Edward, Körbel, Markus, O’Brien-Ball, Caitlin, McColl, James, Chen, Kevin Y., Kotowski, Mateusz, Humphrey, Jane, Lippert, Anna H., Brouwer, Heather, Santos, Ana Mafalda, Lee, Steven F., Davis, Simon J., Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036606/
https://www.ncbi.nlm.nih.gov/pubmed/36959206
http://dx.doi.org/10.1038/s41467-023-36855-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036606/
https://www.ncbi.nlm.nih.gov/pubmed/36959206
http://dx.doi.org/10.1038/s41467-023-36855-9

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