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FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
Amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau), missense mutations in tau enhance its aggregation propensity. Here we describe the structural mechanism for how an FTD-tau S320F mutatio...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036635/ https://www.ncbi.nlm.nih.gov/pubmed/36959205 http://dx.doi.org/10.1038/s41467-023-37274-6 |