FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

Amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau), missense mutations in tau enhance its aggregation propensity. Here we describe the structural mechanism for how an FTD-tau S320F mutatio...

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Detalles Bibliográficos
Autores principales: Chen, Dailu, Bali, Sofia, Singh, Ruhar, Wosztyl, Aleksandra, Mullapudi, Vishruth, Vaquer-Alicea, Jaime, Jayan, Parvathy, Melhem, Shamiram, Seelaar, Harro, van Swieten, John C., Diamond, Marc I., Joachimiak, Lukasz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036635/
https://www.ncbi.nlm.nih.gov/pubmed/36959205
http://dx.doi.org/10.1038/s41467-023-37274-6

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