Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses

Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyte activation and differentiation, and differential gene expre...

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Detalles Bibliográficos
Autores principales: Muchamuel, Tony, Fan, R. Andrea, Anderl, Janet L., Bomba, Darrin J., Johnson, Henry W. B., Lowe, Eric, Tuch, Brian B., McMinn, Dustin L., Millare, Beatriz, Kirk, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036830/
https://www.ncbi.nlm.nih.gov/pubmed/36969170
http://dx.doi.org/10.3389/fimmu.2023.1043680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036830/
https://www.ncbi.nlm.nih.gov/pubmed/36969170
http://dx.doi.org/10.3389/fimmu.2023.1043680

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