Targeting lysosomal HSP70 induces acid sphingomyelinase‐mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies

BACKGROUND: T cell malignancies proliferate vigorously, are highly dependent on lysosomal function, with limited therapeutic options. Deregulation of lysosomal structure and function has been confirmed to be a key role in the treatment of hematologic malignant disease. METHODS: Cell counting kit 8 a...

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Detalles Bibliográficos
Autores principales: Qing, Yingjie, Guo, Yongjian, Zhao, Qinwen, Hu, Po, Li, Hui, Yu, Xiaoxuan, Zhu, Mengyuan, Wang, Hongzheng, Wang, Zhanyu, Xu, Jingyan, Guo, Qinglong, Hui, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036880/
https://www.ncbi.nlm.nih.gov/pubmed/36959764
http://dx.doi.org/10.1002/ctm2.1229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036880/
https://www.ncbi.nlm.nih.gov/pubmed/36959764
http://dx.doi.org/10.1002/ctm2.1229

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