Cargando…

Chemical Knockdown of Phosphorylated p38 Mitogen-Activated Protein Kinase (MAPK) as a Novel Approach for the Treatment of Alzheimer′s Disease

[Image: see text] Targeted protein degradation (TPD) provides unique advantages over gene knockdown in that it can induce selective degradation of disease-associated proteins attributed to pathological mutations or aberrant post-translational modifications (PTMs). Herein, we report a protein degrade...

Descripción completa

Detalles Bibliográficos
Autores principales:	Son, Seung Hwan, Lee, Na-Rae, Gee, Min Sung, Song, Chae Won, Lee, Soo Jin, Lee, Sang-Kyung, Lee, Yoonji, Kim, Hee Jin, Lee, Jong Kil, Inn, Kyung-Soo, Kim, Nam-Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037464/ https://www.ncbi.nlm.nih.gov/pubmed/36968534 http://dx.doi.org/10.1021/acscentsci.2c01369

Ejemplares similares

A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
por: Gee, Min Sung, et al.
Publicado: (2020)

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease
por: Lee, Jong Kil, et al.
Publicado: (2017)

Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog–Thalidomide PROTACs
por: Kim, Ga Yeong, et al.
Publicado: (2021)

Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase
por: Hassan, Ahmed H. E., et al.
Publicado: (2023)

Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK
por: Lee, Choon-Soo, et al.
Publicado: (2021)

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling
por: Ban, Junsu, et al.
Publicado: (2018)

Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
por: Lee, Na-Rae, et al.
Publicado: (2015)

Dual-Specificity Phosphatase 10 Controls Brown Adipocyte Differentiation by Modulating the Phosphorylation of P38 Mitogen-Activated Protein Kinase
por: Choi, Hye-Ryung, et al.
Publicado: (2013)

Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis
por: Lee, Na-Rae, et al.
Publicado: (2018)

NJK14047 Suppression of the p38 MAPK Ameliorates OVA-Induced Allergic Asthma during Sensitization and Challenge Periods
por: Lee, Ju-Hyun, et al.
Publicado: (2023)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
por: Lee, Ju-Hyun, et al.
Publicado: (2022)

p38 MAPK activity is associated with the histological degree of interstitial fibrosis in IgA nephropathy patients
por: Lee, Jeonghwan, et al.
Publicado: (2019)

Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation
por: Lee, Minho, et al.
Publicado: (2017)

Synthetic 3′,4′-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model
por: Kim, Namkwon, et al.
Publicado: (2018)

Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38
por: Chen, Jian, et al.
Publicado: (2021)

Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction
por: Chen, Hongmei, et al.
Publicado: (2005)

Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway
por: Park, Tae-Jun, et al.
Publicado: (2021)

Renal Dysfunction and Tubulopathy Induced by High-Dose Tenofovir Disoproxil Fumarate in C57BL/6 Mice
por: Jang, Eungyeong, et al.
Publicado: (2020)

Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation
por: Yoo, Miran, et al.
Publicado: (2016)

Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer’s disease mouse model
por: Kim, Namkwon, et al.
Publicado: (2023)

Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling
por: Lee, Ki Mo, et al.
Publicado: (2015)

Cardiotonic pill attenuates white matter and hippocampal damage via inhibiting microglial activation and downregulating ERK and p38 MAPK signaling in chronic cerebral hypoperfused rat
por: Lee, Ki Mo, et al.
Publicado: (2013)

Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK–MuRF-1 Pathway in Rats
por: Ryu, Yunkyoung, et al.
Publicado: (2019)

Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition
por: Byun, Hyun Jung, et al.
Publicado: (2013)

A p38 MAPK-Mediated Alteration of COX-2/PGE(2) Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging
por: Yu, Kyung-Rok, et al.
Publicado: (2014)

Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
por: Youn, Cha Kyung, et al.
Publicado: (2013)

Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK-Dependent ROS
por: Lee, Sei Young, et al.
Publicado: (2014)

Bakuchiol Suppresses Inflammatory Responses Via the Downregulation of the p38 MAPK/ERK Signaling Pathway
por: Lim, Hye-Sun, et al.
Publicado: (2019)

New aspects of p38 mitogen activated protein kinase (MAPK) biology in lung inflammation
por: Newton, Robert, et al.
Publicado: (2006)

Aldosterone Upregulates Connective Tissue Growth Factor Gene Expression via p38 MAPK Pathway and Mineralocorticoid Receptor in Ventricular Myocytes
por: Lee, Young-Sam, et al.
Publicado: (2004)

MicroRNA-139-5p Regulates Fibrotic Potentials via Modulation of Collagen Type 1 and Phosphorylated p38 MAPK in Uterine Leiomyoma
por: Ahn, So Hyun, et al.
Publicado: (2021)

EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells
por: Chun, Kyung-Soo, et al.
Publicado: (2015)

JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection
por: Lee, Changhee, et al.
Publicado: (2016)

A Survey of Therapeutic Effects of Artemisia capillaris in Liver Diseases
por: Jang, Eungyeong, et al.
Publicado: (2015)

Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
por: Kim, Seok Jai, et al.
Publicado: (2012)

Hypochoeris radicata attenuates LPS-induced inflammation by suppressing p38, ERK, and JNK phosphorylation in RAW 264.7 macrophages
por: Kim, Min-Jin, et al.
Publicado: (2014)

Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK-mediated DR5 regulation in colorectal cancer
por: Kim, Se-Lim, et al.
Publicado: (2019)

The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways
por: Lee, Hee Jeong, et al.
Publicado: (2018)

Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Rectal Cancer: Long-Term Results after Protocol-Based Treatment
por: Lee, Dong Soo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rage0mqs92e8i1u3fc38hd6dcd