Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

BACKGROUND: Serine hydroxymethyltransferase 2 (SHMT2) catalyzes the reversible conversion of tetrahydrofolate (THF) and serine-producing THF-conjugated one-carbon units and glycine in the mitochondria. Biallelic SHMT2 variants were identified in humans and suggested to alter the protein’s active sit...

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Detalles Bibliográficos
Autores principales: Fiddler, Joanna L., Blum, Jamie E., Heyden, Katarina E., Castillo, Luisa F., Thalacker-Mercer, Anna E., Field, Martha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037823/
https://www.ncbi.nlm.nih.gov/pubmed/36959541
http://dx.doi.org/10.1186/s12263-023-00724-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037823/
https://www.ncbi.nlm.nih.gov/pubmed/36959541
http://dx.doi.org/10.1186/s12263-023-00724-3

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