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Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues
Prions are infectious protein particles known to cause prion diseases. The biochemical entity of the pathogen is the misfolded prion protein (PrP(Sc)) that forms insoluble amyloids to impair brain function. PrP(Sc) interacts with the non-pathogenic, cellular prion protein (PrP(C)) and facilitates co...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038035/ https://www.ncbi.nlm.nih.gov/pubmed/36950944 http://dx.doi.org/10.1080/14756366.2023.2191164 |