Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions

Early assessment of dosing requirements should be an integral part of developability assessments for a discovery program. If a very high dose is required to achieve the desired pharmacological effect, it may not be clinically feasible or commercially desirable to develop the biotherapeutic for the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Grant, Joshuaine, Hua, Fei, Apgar, Joshua F., Burke, John M., Marcantonio, Diana H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038042/
https://www.ncbi.nlm.nih.gov/pubmed/36951503
http://dx.doi.org/10.1080/19420862.2023.2192251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038042/
https://www.ncbi.nlm.nih.gov/pubmed/36951503
http://dx.doi.org/10.1080/19420862.2023.2192251

Ejemplares similares