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Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions
Early assessment of dosing requirements should be an integral part of developability assessments for a discovery program. If a very high dose is required to achieve the desired pharmacological effect, it may not be clinically feasible or commercially desirable to develop the biotherapeutic for the s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038042/ https://www.ncbi.nlm.nih.gov/pubmed/36951503 http://dx.doi.org/10.1080/19420862.2023.2192251 |