Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells

The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous system leukemia(CNSL) incidence. Decreasing of cel...

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Autores principales: Huang, Lan, Zhu, Yao, Kong, Qinglin, Guan, Xianmin, Lei, Xiaoying, Zhang, Luying, Yang, Hui, Yao, Xinyuan, Liang, Shaoyan, An, Xizhou, Yu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038045/
https://www.ncbi.nlm.nih.gov/pubmed/36944577
http://dx.doi.org/10.1080/19336918.2023.2191913
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author Huang, Lan
Zhu, Yao
Kong, Qinglin
Guan, Xianmin
Lei, Xiaoying
Zhang, Luying
Yang, Hui
Yao, Xinyuan
Liang, Shaoyan
An, Xizhou
Yu, Jie
author_facet Huang, Lan
Zhu, Yao
Kong, Qinglin
Guan, Xianmin
Lei, Xiaoying
Zhang, Luying
Yang, Hui
Yao, Xinyuan
Liang, Shaoyan
An, Xizhou
Yu, Jie
author_sort Huang, Lan
collection PubMed
description The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous system leukemia(CNSL) incidence. Decreasing of cell invasion was observed in Jurkat and Molt4 treated with integrin αvβ3 specific antibody and inhibitor as well as cells with ITGB3 interference. Further, phosphorylation of FAK, cRAF, MEK and ERK decreased in cells with integrin αvβ3 inhibition or interference. Invasion decreased in T-ALL cells treated with FAK and ERK inhibitors. In conclusion, inhibition of integrin αvβ3 signals significantly limits the cell invasion of T-ALL cells.
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spelling pubmed-100380452023-03-25 Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells Huang, Lan Zhu, Yao Kong, Qinglin Guan, Xianmin Lei, Xiaoying Zhang, Luying Yang, Hui Yao, Xinyuan Liang, Shaoyan An, Xizhou Yu, Jie Cell Adh Migr Research Paper The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous system leukemia(CNSL) incidence. Decreasing of cell invasion was observed in Jurkat and Molt4 treated with integrin αvβ3 specific antibody and inhibitor as well as cells with ITGB3 interference. Further, phosphorylation of FAK, cRAF, MEK and ERK decreased in cells with integrin αvβ3 inhibition or interference. Invasion decreased in T-ALL cells treated with FAK and ERK inhibitors. In conclusion, inhibition of integrin αvβ3 signals significantly limits the cell invasion of T-ALL cells. Taylor & Francis 2023-03-21 /pmc/articles/PMC10038045/ /pubmed/36944577 http://dx.doi.org/10.1080/19336918.2023.2191913 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Paper
Huang, Lan
Zhu, Yao
Kong, Qinglin
Guan, Xianmin
Lei, Xiaoying
Zhang, Luying
Yang, Hui
Yao, Xinyuan
Liang, Shaoyan
An, Xizhou
Yu, Jie
Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells
title Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells
title_full Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells
title_fullStr Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells
title_full_unstemmed Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells
title_short Inhibition of Integrin α(v)β(3)-FAK-MAPK signaling constrains the invasion of T-ALL cells
title_sort inhibition of integrin α(v)β(3)-fak-mapk signaling constrains the invasion of t-all cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038045/
https://www.ncbi.nlm.nih.gov/pubmed/36944577
http://dx.doi.org/10.1080/19336918.2023.2191913
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