Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins. [Sarcosine(1)Ile(4)Ile(8)]-angiotensin II (SII), an analog of the endogenous ligand angiotensin II (AngII) for the angiotensin II type 1 rece...

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Detalles Bibliográficos
Autores principales: Li, Angus, Liu, Samuel, Huang, Rennica, Ahn, Seungkirl, Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038289/
https://www.ncbi.nlm.nih.gov/pubmed/36961836
http://dx.doi.org/10.1371/journal.pone.0283477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038289/
https://www.ncbi.nlm.nih.gov/pubmed/36961836
http://dx.doi.org/10.1371/journal.pone.0283477

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