Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

PARP1 and PARP2 detect DNA breaks, which activates their catalytic production of poly(ADP-ribose) that recruits repair factors and contributes to PARP1/2 release from DNA. PARP inhibitors (PARPi) are used in cancer treatment and target PARP1/2 catalytic activity, interfering with repair and increasi...

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Detalles Bibliográficos
Autores principales: Langelier, Marie-France, Lin, Xiaohui, Zha, Shan, Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038340/
https://www.ncbi.nlm.nih.gov/pubmed/36961901
http://dx.doi.org/10.1126/sciadv.adf7175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038340/
https://www.ncbi.nlm.nih.gov/pubmed/36961901
http://dx.doi.org/10.1126/sciadv.adf7175

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