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Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

PARP1 and PARP2 detect DNA breaks, which activates their catalytic production of poly(ADP-ribose) that recruits repair factors and contributes to PARP1/2 release from DNA. PARP inhibitors (PARPi) are used in cancer treatment and target PARP1/2 catalytic activity, interfering with repair and increasi...

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Detalles Bibliográficos
Autores principales:	Langelier, Marie-France, Lin, Xiaohui, Zha, Shan, Pascal, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038340/ https://www.ncbi.nlm.nih.gov/pubmed/36961901 http://dx.doi.org/10.1126/sciadv.adf7175

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