Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype

PURPOSE: Poor metabolizers (PMs) of the highly polymorphic enzyme CYP2D6 are usually at high risk of adverse effects during standard recommended dosing of CYP2D6-metabolized drugs. We studied if the metabolism of solanidine, a dietary compound found in potatoes, could serve as a biomarker predicting...

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Detalles Bibliográficos
Autores principales: Wollmann, Birgit M., Størset, Elisabet, Kringen, Marianne Kristiansen, Molden, Espen, Smith, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038974/
https://www.ncbi.nlm.nih.gov/pubmed/36806969
http://dx.doi.org/10.1007/s00228-023-03462-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038974/
https://www.ncbi.nlm.nih.gov/pubmed/36806969
http://dx.doi.org/10.1007/s00228-023-03462-y

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