Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite inten...

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Detalles Bibliográficos
Autores principales: Sharma, Jaiprakash, Mulherkar, Shalaka, Chen, Uan-I, Xiong, Yan, Bajaj, Lakshya, Cho, Byoung-Kyu, Goo, Young Ah, Leung, Hon-Chiu Eastwood, Tolias, Kimberley F., Sardiello, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038992/
https://www.ncbi.nlm.nih.gov/pubmed/36964131
http://dx.doi.org/10.1038/s41421-023-00533-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038992/
https://www.ncbi.nlm.nih.gov/pubmed/36964131
http://dx.doi.org/10.1038/s41421-023-00533-3

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