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Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination
Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite inten...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Nature Singapore
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038992/ https://www.ncbi.nlm.nih.gov/pubmed/36964131 http://dx.doi.org/10.1038/s41421-023-00533-3 |