Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity

During intracellular infection, T follicular helper (T(FH)) and T helper 1 (T(H)1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8(+) T cells. The mechanisms...

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Detalles Bibliográficos
Autores principales: Read, Kaitlin A., Jones, Devin M., Pokhrel, Srijana, Hales, Emily D. S., Varkey, Aditi, Tuazon, Jasmine A., Eisele, Caprice D., Abdouni, Omar, Saadey, Abbey, Leonard, Melissa R., Warren, Robert T., Powell, Michael D., Boss, Jeremy M., Hemann, Emily A., Yount, Jacob S., Xin, Gang, Ghoneim, Hazem E., Lio, Chan-Wang J., Freud, Aharon G., Collins, Patrick L., Oestreich, Kenneth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039023/
https://www.ncbi.nlm.nih.gov/pubmed/36964178
http://dx.doi.org/10.1038/s41467-023-37420-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039023/
https://www.ncbi.nlm.nih.gov/pubmed/36964178
http://dx.doi.org/10.1038/s41467-023-37420-0

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