Cargando…

Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity

During intracellular infection, T follicular helper (T(FH)) and T helper 1 (T(H)1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8(+) T cells. The mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Read, Kaitlin A., Jones, Devin M., Pokhrel, Srijana, Hales, Emily D. S., Varkey, Aditi, Tuazon, Jasmine A., Eisele, Caprice D., Abdouni, Omar, Saadey, Abbey, Leonard, Melissa R., Warren, Robert T., Powell, Michael D., Boss, Jeremy M., Hemann, Emily A., Yount, Jacob S., Xin, Gang, Ghoneim, Hazem E., Lio, Chan-Wang J., Freud, Aharon G., Collins, Patrick L., Oestreich, Kenneth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039023/ https://www.ncbi.nlm.nih.gov/pubmed/36964178 http://dx.doi.org/10.1038/s41467-023-37420-0

Ejemplares similares

Aiolos and Lymphocyte Mimicry in Lung Cancer
por: Terada, Lance S, et al.
Publicado: (2014)

Aiolos regulates eosinophil migration into tissues
por: Felton, Jennifer M., et al.
Publicado: (2021)

AIOLOS Variants Causing Immunodeficiency in Human and Mice
por: Yamashita, Motoi, et al.
Publicado: (2022)

IL-7 signalling represses Bcl-6 and the T(FH) gene program
por: McDonald, Paul W., et al.
Publicado: (2016)

IL-12 signaling drives the differentiation and function of a T(H)1-derived T(FH1)-like cell population
por: Powell, Michael D., et al.
Publicado: (2019)

T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients
por: Kuehn, Hye Sun, et al.
Publicado: (2021)

IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4(+) T Cells
por: Ridley, Michael L., et al.
Publicado: (2020)

Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity
por: Qiu, Jinxin, et al.
Publicado: (2021)

Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
por: Hagner, Patrick R., et al.
Publicado: (2022)

Molecular mechanisms that control the expression and activity of Bcl-6 in T(H)1 cells to regulate flexibility with a T(FH)-like gene profile
por: Oestreich, Kenneth J., et al.
Publicado: (2012)

FH through the retrospectoscope
por: Thompson, Gilbert R.
Publicado: (2021)

Familial Hypercholesterolemia (FH) in Iran: Findings from the Four-Year FH Registry
por: Vaseghi, Golnaz, et al.
Publicado: (2021)

Aiolos Is Required for the Generation of High Affinity Bone Marrow Plasma Cells Responsible for Long-Term Immunity
por: Cortés, Marta, et al.
Publicado: (2004)

Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus
por: Rivellese, Felice, et al.
Publicado: (2021)

The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry
por: Alallaf, Faisal, et al.
Publicado: (2017)

Tox2 is required for the maintenance of GC T(FH) cells and the generation of memory T(FH) cells
por: Horiuchi, Shu, et al.
Publicado: (2021)

Update on the FH01 study
por: Duffy, SW
Publicado: (2006)

Genetic Mapping and Allelic Loss Analysis in Mouse Thymic Lymphomas of Helios and Aiolos Belonging to the Ikaros Gene Family
por: Xu, Hongbin, et al.
Publicado: (2001)

Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells
por: Hung, Jung-Jyh, et al.
Publicado: (2019)

A comparative sequence analysis reveals a common GBD/FH3-FH1-FH2-DAD architecture in formins from Dictyostelium, fungi and metazoa
por: Rivero, Francisco, et al.
Publicado: (2005)

Pharmacogenetic aspects in familial hypercholesterolemia with the special focus on FH(Marburg) (FH p.W556R)
por: Schaefer, Juergen R., et al.
Publicado: (2012)

HIRA loss transforms FH-deficient cells
por: Valcarcel-Jimenez, Lorea, et al.
Publicado: (2022)

Silencing and Nuclear Repositioning of the λ5 Gene Locus at the Pre-B Cell Stage Requires Aiolos and OBF-1
por: Karnowski, Alexander, et al.
Publicado: (2008)

Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them
por: Cippitelli, Marco, et al.
Publicado: (2021)

Cascade Screening for Familial Hypercholesterolemia (FH)
por: Ned, Renée M., et al.
Publicado: (2011)

The Succinated Proteome of FH-Mutant Tumours
por: Yang, Ming, et al.
Publicado: (2014)

Common Variable Immunodeficiency and Circulating T(FH)
por: Coraglia, Ana, et al.
Publicado: (2016)

Shortcomings on genetic testing of Familial hypercholesterolemia (FH) in India: Can we collaborate to establish Indian FH registry?
por: Reddy, Lakshmi Lavanya, et al.
Publicado: (2022)

Homozygous familial hypercholesterolemia (HoFH) in Germany: an epidemiological survey
por: Walzer, S, et al.
Publicado: (2013)

Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus
por: Schafer, Peter H, et al.
Publicado: (2018)

Author Correction: Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells
por: Hung, Jung-Jyh, et al.
Publicado: (2020)

Human Factor H (FH) Impairs Protective Meningococcal Anti-FHbp Antibody Responses and the Antibodies Enhance FH Binding
por: Costa, Isabella, et al.
Publicado: (2014)

ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
por: Kastelein, John J.P., et al.
Publicado: (2015)

Editorial: Molecular and Cellular Pathways in NK Cell Development
por: Sitnicka, Ewa, et al.
Publicado: (2020)

Mechanisms of FH Protection Against Neovascular AMD
por: Borras, Céline, et al.
Publicado: (2020)

FH535 Inhibited Migration and Growth of Breast Cancer Cells
por: Iida, Joji, et al.
Publicado: (2012)

A Case of Renal Cell Carcinoma and Pheochromocytoma Due to Germline Inactivating Mutation in Fumarate Hydratase (FH)
por: Reda, Sarah Alicia, et al.
Publicado: (2021)

T Cell Polarization toward T(H)2/T(FH)2 and T(H)17/T(FH)17 in Patients with IgG4-Related Disease
por: Grados, Aurélie, et al.
Publicado: (2017)

Lenalidomide combined with low-dose cyclophosphamide and prednisone modulates Ikaros and Aiolos in lymphocytes, resulting in immunostimulatory effects in lenalidomide-refractory multiple myeloma patients
por: Franssen, Laurens E., et al.
Publicado: (2018)

Activin A programs human T(FH) cell differentiation
por: Locci, Michela, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1r2gg67bfb4bgqf1d8s2h4p2uj