Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets

Chemically induced proximity (CIP) is a powerful tool to study cellular functions. However with current CIP inducers it is difficult to directly modulate unligandable and endogenous targets, and therapeutic translational potential is also restricted. Herein, we combine CIP and chemical nanobody engi...

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Detalles Bibliográficos
Autores principales: Sun, Xiaofeng, Zhou, Chengjian, Xia, Simin, Chen, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039045/
https://www.ncbi.nlm.nih.gov/pubmed/36964170
http://dx.doi.org/10.1038/s41467-023-37237-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039045/
https://www.ncbi.nlm.nih.gov/pubmed/36964170
http://dx.doi.org/10.1038/s41467-023-37237-x

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