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Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets
Chemically induced proximity (CIP) is a powerful tool to study cellular functions. However with current CIP inducers it is difficult to directly modulate unligandable and endogenous targets, and therapeutic translational potential is also restricted. Herein, we combine CIP and chemical nanobody engi...
Autores principales: | Sun, Xiaofeng, Zhou, Chengjian, Xia, Simin, Chen, Xi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039045/ https://www.ncbi.nlm.nih.gov/pubmed/36964170 http://dx.doi.org/10.1038/s41467-023-37237-x |
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