Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1

BACKGROUND: The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress that is induced by incomplete RFA are the main source of HCC relapse. Heat stress has long been reported to increase intrace...

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Detalles Bibliográficos
Autores principales: Peng, Chao, Li, Xi, Ao, Feng, Li, Ting, Guo, Jingpei, Liu, Junfeng, Zhang, Xiaoting, Gu, Jinyan, Mao, Junjie, Zhou, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039571/
https://www.ncbi.nlm.nih.gov/pubmed/36964576
http://dx.doi.org/10.1186/s12967-023-04067-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039571/
https://www.ncbi.nlm.nih.gov/pubmed/36964576
http://dx.doi.org/10.1186/s12967-023-04067-w

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