Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zone

Septins are filamentous GTPases that play important but poorly characterized roles in ciliogenesis. Here, we show that SEPTIN9 regulates RhoA signaling at the base of cilia by binding and activating the RhoA guanine nucleotide exchange factor, ARHGEF18. GTP-RhoA is known to activate the membrane tar...

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Detalles Bibliográficos
Autores principales: Safavian, Darya, Kim, Moshe S., Xie, Hong, El-Zeiry, Maha, Palander, Oliva, Dai, Lu, Collins, Richard F., Froese, Carol, Shannon, Rachel, Nagata, Koh-ichi, Trimble, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039714/
https://www.ncbi.nlm.nih.gov/pubmed/36912772
http://dx.doi.org/10.1083/jcb.201911062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039714/
https://www.ncbi.nlm.nih.gov/pubmed/36912772
http://dx.doi.org/10.1083/jcb.201911062

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