Increasing the melting temperature of VHH with the in silico free energy score

VHH, the antigen-binding fragment of a heavy chain-only antibody, is a useful component of antibody-based therapeutics. Thermal stability, represented by the melting temperature (Tm), is one of the key factors affecting the developability of antibody-based therapeutics. In this study, we examined wh...

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Detalles Bibliográficos
Autores principales: Tomimoto, Yusuke, Yamazaki, Rika, Shirai, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039853/
https://www.ncbi.nlm.nih.gov/pubmed/36966210
http://dx.doi.org/10.1038/s41598-023-32022-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039853/
https://www.ncbi.nlm.nih.gov/pubmed/36966210
http://dx.doi.org/10.1038/s41598-023-32022-8

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