Cargando…

Synthesis and biological evaluation of substituted acetamide derivatives as potential butyrylcholinestrase inhibitors

Alzheimer’s disease (AD) is the most common type of age-related dementia. Inhibition of butyrylcholinesterase (BChE) emerge as an effective therapeutic target for AD. A series of new substituted acetamide derivatives were designed, synthesized and evaluated for their ability to inhibit BChE. The bio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Dehong, Yang, Can, Liu, Yi, Lu, Tao, Li, Lizi, Chen, Gang, Liu, Zerong, Li, Yanfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039877/ https://www.ncbi.nlm.nih.gov/pubmed/36966194 http://dx.doi.org/10.1038/s41598-023-31849-5

Ejemplares similares

Coumarin derivatives as acetyl- and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study
por: Abu-Aisheh, Marwa N., et al.
Publicado: (2019)

Design, synthesis, and biological evaluation of novel N(4)-substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors
por: Hussein, Essam M., et al.
Publicado: (2019)

Synthesis, biological and computational studies of flavonoid acetamide derivatives
por: Isika, Daniel K., et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel Thienylpyridyl- and Thioether-Containing Acetamides and Their Derivatives as Pesticidal Agents
por: Li, Huan, et al.
Publicado: (2021)

Bis-pyrimidine acetamides: design, synthesis and biological evaluation
por: Kumar, Sanjiv, et al.
Publicado: (2017)

Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors
por: Liu, Yi, et al.
Publicado: (2022)

Antibacterial Potential of Novel Acetamide Derivatives of 2-Mercaptobenzothiazole: Synthesis and Docking Studies
por: Sheikh, Ahmed Sadiq, et al.
Publicado: (2023)

Synthesis, Antibacterial Evaluation and QSAR of α-Substituted-N(4)-Acetamides of Ciprofloxacin and Norfloxacin
por: Qandil, Amjad M., et al.
Publicado: (2014)

Anticancer, Anti-Inflammatory, and Analgesic Activities of Synthesized 2-(Substituted phenoxy) Acetamide Derivatives
por: Rani, Priyanka, et al.
Publicado: (2014)

Synthesis, In Silico and In Vitro Characterization of Novel N,N-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)
por: Park, Jaekyung, et al.
Publicado: (2023)

Novel quercetin and apigenin-acetamide derivatives: design, synthesis, characterization, biological evaluation and molecular docking studies
por: Isika, Daniel, et al.
Publicado: (2020)

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
por: Paszkowska, Jadwiga, et al.
Publicado: (2013)

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors
por: Nasli Esfahani, Anita, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
por: Zhou, Wei-Ming, et al.
Publicado: (2010)

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies
por: Bacha, Mohsinul Mulk, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of N,N-Substituted Amine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors
por: Wang, Xinran, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents
por: Wu, Tong, et al.
Publicado: (2018)

Synthesis of N-(6-Arylbenzo[d]thiazole-2-acetamide Derivatives and Their Biological Activities: An Experimental and Computational Approach
por: Gull, Yasmeen, et al.
Publicado: (2016)

Design, synthesis, and cytotoxic evaluation of quinazoline derivatives bearing triazole-acetamides
por: Pedrood, Keyvan, et al.
Publicado: (2023)

Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
por: Autore, Giuseppina, et al.
Publicado: (2010)

New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: design, synthesis, in vitro inhibition, and molecular dynamic simulation
por: Dastyafteh, Navid, et al.
Publicado: (2023)

Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives
por: Zhen, Xinghua, et al.
Publicado: (2015)

Synthesis, Properties and Biological Activity of Organotitanium Substituted Heteropolytungstates
por: Wang, Xiaohong, et al.
Publicado: (2001)

Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety
por: Shang, Ruofeng, et al.
Publicado: (2013)

Synthesis, characterization and biological activity of a niobium-substituted-heteropolytungstate on hepatitis B virus
por: Zhang, Hong, et al.
Publicado: (2012)

A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation
por: Zhang, Jiwei, et al.
Publicado: (2023)

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides
por: Yadav, Snehlata, et al.
Publicado: (2017)

Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
por: Noori, Milad, et al.
Publicado: (2022)

2-Cyano-N,N-dimethylacetamide
por: Liu, Shan, et al.
Publicado: (2012)

Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties
por: Jin, Yun-Zhou, et al.
Publicado: (2011)

N-(4-Hydroxyphenethyl)acetamide
por: Wang, Bo, et al.
Publicado: (2009)

Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities
por: Abdel Moty, Samia G., et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Achiral Indole-Substituted Titanocene Dichloride Derivatives
por: Deally, Anthony, et al.
Publicado: (2012)

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation
por: Zhu, Jin, et al.
Publicado: (2009)

Synthesis and Biological Evaluation of Thiazole-Based Derivatives as Potential Acetylcholinesterase Inhibitors
por: Hemaida, Aya Y., et al.
Publicado: (2021)

Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents
por: Wei, Jinbao, et al.
Publicado: (2019)

Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles
por: Yao, Kun, et al.
Publicado: (2018)

Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents
por: An, Ran, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents
por: Zhang, Dongfeng, et al.
Publicado: (2014)

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII
por: Mahammad Ghouse, Shaik, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_un2j2huk491j8b8gbrl0g7hhnp