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Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis

Synucleinopathies are neurodegenerative diseases characterized by pathological inclusions called “Lewy pathology” (LP) that consist of aggregated alpha-synuclein predominantly phosphorylated at serine 129 (PSER129). Despite the importance for understanding disease, little is known about the endogeno...

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Detalles Bibliográficos
Autores principales: Killinger, Bryan A., Mercado, Gabriela, Choi, Solji, Tittle, Tyler, Chu, Yaping, Brundin, Patrik, Kordower, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039879/
https://www.ncbi.nlm.nih.gov/pubmed/36966145
http://dx.doi.org/10.1038/s41531-023-00491-3