Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes

Deubiquitinating enzymes are key regulators in the ubiquitin system and an emerging class of drug targets. These proteases disassemble polyubiquitin chains and many deubiquitinases show selectivity for specific polyubiquitin linkages. However, most biochemical insights originate from studies of sing...

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Detalles Bibliográficos
Autores principales: van Tol, Bianca D. M., van Doodewaerd, Bjorn R., Lageveen-Kammeijer, Guinevere S. M., Jansen, Bas C., Talavera Ormeño, Cami M. P., Hekking, Paul J. M., Sapmaz, Aysegul, Kim, Robbert Q., Moutsiopoulou, Angeliki, Komander, David, Wuhrer, Manfred, van der Heden van Noort, Gerbrand J., Ovaa, Huib, Geurink, Paul P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039891/
https://www.ncbi.nlm.nih.gov/pubmed/36966155
http://dx.doi.org/10.1038/s41467-023-37363-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039891/
https://www.ncbi.nlm.nih.gov/pubmed/36966155
http://dx.doi.org/10.1038/s41467-023-37363-6

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