Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells

The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation. Neurotrophin receptors (NTRs) were significantly upregulated in myoepithelial cells...

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Detalles Bibliográficos
Autores principales: Chibly, Alejandro M., Patel, Vaishali N., Aure, Marit H., Pasquale, Mary C., Martin, Gemma E., Ghannam, Mousa, Andrade, Julianne, Denegre, Noah G., Simpson, Colleen, Goldstein, David P., Liu, Fei-Fei, Lombaert, Isabelle M. A., Hoffman, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039923/
https://www.ncbi.nlm.nih.gov/pubmed/36966175
http://dx.doi.org/10.1038/s41536-023-00290-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039923/
https://www.ncbi.nlm.nih.gov/pubmed/36966175
http://dx.doi.org/10.1038/s41536-023-00290-7

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