Cargando…

Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect

Multiple sclerosis (MS) is an auto-immune inflammatory disorder affecting the central nervous system. The cause of the disease is unknown but both genetic and environmental factors are implicated in the pathogenesis. We derived cerebral organoids from induced pluripotent stem cells (iPSC) of healthy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daviaud, Nicolas, Chen, Eric, Edwards, Tara, Sadiq, Saud A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040243/ https://www.ncbi.nlm.nih.gov/pubmed/36744877 http://dx.doi.org/10.1242/bio.059845

Ejemplares similares

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells
por: Douvaras, Panagiotis, et al.
Publicado: (2014)

Vascularization and Engraftment of Transplanted Human Cerebral Organoids in Mouse Cortex
por: Daviaud, Nicolas, et al.
Publicado: (2018)

TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques
por: de Faria, Omar, et al.
Publicado: (2019)

Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury
por: Daviaud, Nicolas, et al.
Publicado: (2019)

Transcriptional abnormalities in induced pluripotent stem cell-derived oligodendrocytes of individuals with primary progressive multiple sclerosis
por: Plastini, Melanie J., et al.
Publicado: (2022)

Cerebrospinal fluid of progressive multiple sclerosis patients reduces differentiation and immune functions of oligodendrocyte progenitor cells
por: Zveik, Omri, et al.
Publicado: (2022)

Oligodendrocyte generation dynamics in multiple sclerosis
por: Yeung, Maggie S.Y., et al.
Publicado: (2019)

Phase I Trial of Intrathecal Mesenchymal Stem Cell-derived Neural Progenitors in Progressive Multiple Sclerosis
por: Harris, Violaine K., et al.
Publicado: (2018)

Altered human oligodendrocyte heterogeneity in multiple sclerosis
por: Jäkel, Sarah, et al.
Publicado: (2019)

Oligodendrocyte Development and Regenerative Therapeutics in Multiple Sclerosis
por: Gacem, Nadjet, et al.
Publicado: (2021)

Biomarkers of Therapeutic Response in Multiple Sclerosis: Current Status
por: Harris, Violaine K., et al.
Publicado: (2014)

Biomarkers of multiple sclerosis: current findings
por: Harris, Violaine K, et al.
Publicado: (2017)

Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis
Publicado: (1994)

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death
por: D'Souza, Sameer D., et al.
Publicado: (1996)

Alterations of Oligodendrocyte and Myelin Energy Metabolism in Multiple Sclerosis
por: López-Muguruza, Eneritz, et al.
Publicado: (2023)

Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids
por: Shaker, Mohammed R., et al.
Publicado: (2021)

Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis
por: Fernandes, Milton Guilherme Forestieri, et al.
Publicado: (2023)

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis
por: Falcão, Ana Mendanha, et al.
Publicado: (2019)

T-cell responses to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis
por: Ewing, C., et al.
Publicado: (1998)

Protocol for generating embedding-free brain organoids enriched with oligodendrocytes
por: Al-mhanawi, Bahaa, et al.
Publicado: (2023)

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
por: Jiang, Peng, et al.
Publicado: (2010)

Mesenchymal stem cell-neural progenitors are enriched in cell signaling molecules implicated in their therapeutic effect in multiple sclerosis
por: Harris, Violaine K., et al.
Publicado: (2023)

Increased Expression of Ephrins on Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis Affects Oligodendrocyte Differentiation
por: Golan, Maya, et al.
Publicado: (2021)

Cerebrospinal fluid immunoglobulins in primary progressive multiple sclerosis are pathogenic
por: Wong, Jamie K, et al.
Publicado: (2023)

CSF isoprostane levels are a biomarker of oxidative stress in multiple sclerosis
por: Mir, Fozia, et al.
Publicado: (2014)

Molecular Mechanisms of Oligodendrocyte Injury in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
por: Patel, Jilpa, et al.
Publicado: (2012)

Semaphorin4A Is Cytotoxic to Oligodendrocytes and Is Elevated in Microglia and Multiple Sclerosis
por: Leitner, Dominique F., et al.
Publicado: (2015)

Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve
por: Jennings, Alison Ruth, et al.
Publicado: (2014)

Effects Mediated by Dimethyl Fumarate on In Vitro Oligodendrocytes: Implications in Multiple Sclerosis
por: Guerriero, Claudia, et al.
Publicado: (2022)

The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies
por: Dulamea, Adriana Octaviana
Publicado: (2017)

Frequency of myelin oligodendrocyte glycoprotein antibody in multiple sclerosis: A multicenter cross-sectional study
por: Cobo-Calvo, Álvaro, et al.
Publicado: (2019)

Dysfunction of the oligodendrocytes in amyotrophic lateral sclerosis
por: Gong, Zhenxiang, et al.
Publicado: (2022)

Astaxanthin Reduces Demyelination and Oligodendrocytes Death in A Rat Model of Multiple Sclerosis
por: Lotfi, Alireza, et al.
Publicado: (2021)

Purinergic Receptors on Oligodendrocyte Progenitors: Promising Targets for Myelin Repair in Multiple Sclerosis?
por: Lecca, Davide, et al.
Publicado: (2021)

Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight
por: Tran, Victoria, et al.
Publicado: (2022)

Stem Cell Therapies for Progressive Multiple Sclerosis
por: Smith, Jayden A., et al.
Publicado: (2021)

A Novel Vitronectin Peptide Facilitates Differentiation of Oligodendrocytes from Human Pluripotent Stem Cells (Synthetic ECM for Oligodendrocyte Differentiation)
por: Park, Won Ung, et al.
Publicado: (2021)

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis
por: Voskuhl, Rhonda R., et al.
Publicado: (2019)

Clobetasol propionate enhances neural stem cell and oligodendrocyte differentiation
por: Shi, Wentao, et al.
Publicado: (2019)

Variation of the Myelin Oligodendrocyte Glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population
por: Marrosu, Maria Giovanna, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_kj9gami65s2hi9uuniqfmbgdrr