mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy

Interleukin-12 (IL-12) gene transfer enhances the therapeutic potency of adoptive T cell therapies. We previously reported that transient engineering of tumor-specific CD8 T cells with IL-12 mRNA enhanced their systemic therapeutic efficacy when delivered intratumorally. Here, we mix T cells enginee...

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Detalles Bibliográficos
Autores principales: Olivera, Irene, Bolaños, Elixabet, Gonzalez-Gomariz, Jose, Hervas-Stubbs, Sandra, Mariño, Karina V., Luri-Rey, Carlos, Etxeberria, Iñaki, Cirella, Assunta, Egea, Josune, Glez-Vaz, Javier, Garasa, Saray, Alvarez, Maite, Eguren-Santamaria, Iñaki, Guedan, Sonia, Sanmamed, Miguel F., Berraondo, Pedro, Rabinovich, Gabriel A., Teijeira, Alvaro, Melero, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040457/
https://www.ncbi.nlm.nih.gov/pubmed/36933554
http://dx.doi.org/10.1016/j.xcrm.2023.100978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040457/
https://www.ncbi.nlm.nih.gov/pubmed/36933554
http://dx.doi.org/10.1016/j.xcrm.2023.100978

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