Cargando…

N(6)-Methyladenosine Methyltransferase METTL3 Alleviates Diabetes-Induced Testicular Damage through Modulating TUG1/Clusterin Axis

BACKGROUND: The present study investigated the regulatory effects of N(6)-methyladenosine (m6A) methyltransferase like-3 (METTL3) in diabetes-induced testicular damage. METHODS: In vivo diabetic mice and high glucose (HG) treated GC-1 spg cells were established. The mRNA and protein expressions were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Yuan, Xiao, Yue-Hai, Sun, Chao, Liu, Bei, Sun, Fa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Diabetes Association 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040629/ https://www.ncbi.nlm.nih.gov/pubmed/36653890 http://dx.doi.org/10.4093/dmj.2021.0306

Ejemplares similares

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

Multifaceted Roles of the N(6)-Methyladenosine RNA Methyltransferase METTL3 in Cancer and Immune Microenvironment
por: Hu, Chenxi, et al.
Publicado: (2022)

METTL14 is a chromatin regulator independent of its RNA N(6)-methyladenosine methyltransferase activity
por: Dou, Xiaoyang, et al.
Publicado: (2023)

The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity
por: Yoshinaga, Masanori, et al.
Publicado: (2022)

N6-Methyladenosine Methyltransferase METTL14-Mediated Autophagy in Malignant Development of Oral Squamous Cell Carcinoma
por: Wang, Fang, et al.
Publicado: (2021)

The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1
por: Shi, Yue, et al.
Publicado: (2021)

N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway
por: Wang, Lin-jian, et al.
Publicado: (2020)

AB212. Clusterin expression and human testicular seminoma
por: Tang, Min, et al.
Publicado: (2014)

Methyltransferase-like (METTL) homologues participate in Nicotiana benthamiana antiviral responses
por: Yue, Jianying, et al.
Publicado: (2023)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer
por: Gong, Peng-Ju, et al.
Publicado: (2020)

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
por: Huang, Wei, et al.
Publicado: (2021)

AB214. Downregulation of clusterin expression in human testicular seminoma
por: Liu, Bianjiang, et al.
Publicado: (2014)

Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α
por: Yang, Zhou, et al.
Publicado: (2021)

The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation
por: Sepich-Poore, Caraline, et al.
Publicado: (2022)

RNA methyltransferase METTL16: Targets and function
por: Satterwhite, Emily R., et al.
Publicado: (2021)

METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
por: Chen, Xiaoxiang, et al.
Publicado: (2020)

METTL3-mediated mRNA N(6)-methyladenosine is required for oocyte and follicle development in mice
por: Mu, Haiyuan, et al.
Publicado: (2021)

Clusterin suppresses invasion and metastasis of testicular seminoma by upregulating COL15a1
por: Cui, Yankang, et al.
Publicado: (2021)

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
por: Chen, Xiaoxiang, et al.
Publicado: (2020)

The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
por: Pan, Fan, et al.
Publicado: (2021)

Structural insights into the RNA methyltransferase domain of METTL16
por: Ruszkowska, Agnieszka, et al.
Publicado: (2018)

N (6)-methyladenosine modification and METTL3 modulate enterovirus 71 replication
por: Hao, Haojie, et al.
Publicado: (2019)

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
por: Ping, Xiao-Li, et al.
Publicado: (2014)

The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma
por: Yao, Qi, et al.
Publicado: (2021)

The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis
por: Zhang, Hui-Min, et al.
Publicado: (2022)

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
por: Kobayashi, Masatoshi, et al.
Publicado: (2018)

N(6)-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract
por: Yang, Jun, et al.
Publicado: (2020)

Retraction Notice to: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
por: Chen, Xiaoxiang, et al.
Publicado: (2022)

N(6)-methyladenosine (m(6)A) methyltransferase METTL3-mediated LINC00680 accelerates osteoarthritis through m(6)A/SIRT1 manner
por: Ren, Jiangdong, et al.
Publicado: (2022)

The role of RNA N(6)-methyladenosine methyltransferase in cancers
por: Huang, Jiali, et al.
Publicado: (2021)

Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer
por: Wang, Qiang, et al.
Publicado: (2020)

The Role of RNA Methyltransferase METTL3 in Normal and Malignant Hematopoiesis
por: Wu, Xia, et al.
Publicado: (2022)

Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis
por: Zhou, Yaqing, et al.
Publicado: (2022)

Functional Characterization of Two RNA Methyltransferase Genes METTL3 and METTL14 Uncovers the Roles of m(6)A in Mediating Adaptation of Plutella xylostella to Host Plants
por: Wang, Bei-Bei, et al.
Publicado: (2022)

METTL3-Mediated N6-Methyladenosine Modification Is Involved in the Dysregulation of NRIP1 Expression in Down Syndrome
por: Shi, Weili, et al.
Publicado: (2021)

m7G Methyltransferase METTL1 Promotes Post-ischemic Angiogenesis via Promoting VEGFA mRNA Translation
por: Zhao, Yongchao, et al.
Publicado: (2021)

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
por: Yue, Ben, et al.
Publicado: (2019)

Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2
por: Yin, Lu, et al.
Publicado: (2022)

Prognostic Roles of N6-Methyladenosine METTL3 in Different Cancers: A System Review and Meta-Analysis
por: Liu, KuangZheng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4vio97deuc4souvn4fcuhcj866