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Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome

BACKGROUND: The mechanism underlying cervical carcinogenesis that is mediated by persistent human papillomavirus (HPV) infection remains elusive. AIMS: Here, for the first time, we deciphered both the temporal transition and spatial distribution of cellular subsets during disease progression from no...

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Detalles Bibliográficos
Autores principales: Guo, Chenyan, Qu, Xinyu, Tang, Xiaoyan, Song, Yu, Wang, Jue, Hua, Keqin, Qiu, Junjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040725/
https://www.ncbi.nlm.nih.gov/pubmed/36967539
http://dx.doi.org/10.1002/ctm2.1219