The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E(2), enhances VEGFR2 activation and promotes angiogenesis

Consecutive oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2 yields the hemiketal eicosanoids, HKE(2) and HKD(2). Hemiketals stimulate angiogenesis by inducing endothelial cell tubulogenesis in culture; however, how this process is regulated has not been determined. Here, we id...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakashima, Fumie, Giménez-Bastida, Juan A., Luis, Paula B., Presley, Sai H., Boer, Robert E., Chiusa, Manuel, Shibata, Takahiro, Sulikowski, Gary A., Pozzi, Ambra, Schneider, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040730/
https://www.ncbi.nlm.nih.gov/pubmed/36813233
http://dx.doi.org/10.1016/j.jbc.2023.103050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040730/
https://www.ncbi.nlm.nih.gov/pubmed/36813233
http://dx.doi.org/10.1016/j.jbc.2023.103050

Ejemplares similares