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The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E(2), enhances VEGFR2 activation and promotes angiogenesis

Consecutive oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2 yields the hemiketal eicosanoids, HKE(2) and HKD(2). Hemiketals stimulate angiogenesis by inducing endothelial cell tubulogenesis in culture; however, how this process is regulated has not been determined. Here, we id...

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Detalles Bibliográficos
Autores principales:	Nakashima, Fumie, Giménez-Bastida, Juan A., Luis, Paula B., Presley, Sai H., Boer, Robert E., Chiusa, Manuel, Shibata, Takahiro, Sulikowski, Gary A., Pozzi, Ambra, Schneider, Claus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040730/ https://www.ncbi.nlm.nih.gov/pubmed/36813233 http://dx.doi.org/10.1016/j.jbc.2023.103050

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