Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease

Sarcopenia is a common and devastating condition in patients with chronic kidney disease (CKD). Here, we provide evidence that the kidney-muscle crosstalk in sarcopenia is mediated by reduced insulin sensitivity and the activation of the muscle-specific isoform of AMP deaminase, AMPD1. By using a hi...

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Detalles Bibliográficos
Autores principales: Andres-Hernando, Ana, Cicerchi, Christina, Garcia, Gabriela E., Orlicky, David J., Stenvinkel, Peter, Johnson, Richard J., Lanaspa, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040733/
https://www.ncbi.nlm.nih.gov/pubmed/36994079
http://dx.doi.org/10.1016/j.isci.2023.106355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040733/
https://www.ncbi.nlm.nih.gov/pubmed/36994079
http://dx.doi.org/10.1016/j.isci.2023.106355

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