Cargando…

The mode of action of tapasin on major histocompatibility class I (MHC-I) molecules

Tapasin (Tsn) plays a critical role in antigen processing and presentation by major histocompatibility complex class I (MHC-I) molecules. The mechanism of Tsn-mediated peptide loading and exchange hinges on the conformational dynamics governing the interaction of Tsn and MHC-I with recent structural...

Descripción completa

Detalles Bibliográficos
Autores principales: Lan, By Huan, Becker, Moritz, Freund, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040737/
https://www.ncbi.nlm.nih.gov/pubmed/36758805
http://dx.doi.org/10.1016/j.jbc.2023.102987