Downregulation of miR-221–3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1

BACKGROUND: Gastric cancer (GC) is an aggressive gastrointestinal tumor. MiRNAs participate in the tumorigenesis of GC. Nevertheless, the function of miR-221–3p in GC remains largely unknown. METHODS: RNA levels were assessed by RT-qPCR. Western blot was performed to test the protein levels. The rel...

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Detalles Bibliográficos
Autores principales: Shao, Chang-Jiang, Zhou, Hai-Lang, Gao, Xu-Zhu, Xu, Chun-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040875/
https://www.ncbi.nlm.nih.gov/pubmed/36947996
http://dx.doi.org/10.1016/j.tranon.2023.101649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040875/
https://www.ncbi.nlm.nih.gov/pubmed/36947996
http://dx.doi.org/10.1016/j.tranon.2023.101649

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