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In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells

Cardiac myosin binding protein-C (cMyBP-C) is a thick filament–associated regulatory protein frequently found mutated in patients suffering from hypertrophic cardiomyopathy (HCM). Recent in vitro experiments have highlighted the functional significance of its N-terminal region (NcMyBP-C) for heart m...

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Detalles Bibliográficos
Autores principales: Chandler, Jessica, Treacy, Conor, Ameer-Beg, Simon, Ehler, Elisabeth, Irving, Malcolm, Kampourakis, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041117/
https://www.ncbi.nlm.nih.gov/pubmed/36913580
http://dx.doi.org/10.1073/pnas.2222005120