OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion

Inner mitochondrial membrane fusion and cristae shape depend on optic atrophy protein 1, OPA1. Mutations in OPA1 lead to autosomal dominant optic atrophy (ADOA), an important cause of inherited blindness. The Guanosin Triphosphatase (GTPase) and GTPase effector domains (GEDs) of OPA1 are essential f...

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Detalles Bibliográficos
Autores principales: Cartes-Saavedra, Benjamín, Lagos, Daniel, Macuada, Josefa, Arancibia, Duxan, Burté, Florence, Sjöberg-Herrera, Marcela K., Andrés, María Estela, Horvath, Rita, Yu-Wai-Man, Patrick, Hajnóczky, György, Eisner, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041121/
https://www.ncbi.nlm.nih.gov/pubmed/36927155
http://dx.doi.org/10.1073/pnas.2207471120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041121/
https://www.ncbi.nlm.nih.gov/pubmed/36927155
http://dx.doi.org/10.1073/pnas.2207471120

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