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Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
The cellular prion protein PrP(C) mediates the neurotoxicity of prions and other protein aggregates through poorly understood mechanisms. Antibody‐derived ligands against the globular domain of PrP(C) (GDL) can also initiate neurotoxicity by inducing an intramolecular R(208)‐H(140) hydrogen bond (“H...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041163/ https://www.ncbi.nlm.nih.gov/pubmed/36329611 http://dx.doi.org/10.1111/bpa.13130 |