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Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity

The cellular prion protein PrP(C) mediates the neurotoxicity of prions and other protein aggregates through poorly understood mechanisms. Antibody‐derived ligands against the globular domain of PrP(C) (GDL) can also initiate neurotoxicity by inducing an intramolecular R(208)‐H(140) hydrogen bond (“H...

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Detalles Bibliográficos
Autores principales:	Reimann, Regina R., Puzio, Martina, Rosati, Antonella, Emmenegger, Marc, Schneider, Bernard L., Valdés, Pamela, Huang, Danzhi, Caflisch, Amedeo, Aguzzi, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041163/ https://www.ncbi.nlm.nih.gov/pubmed/36329611 http://dx.doi.org/10.1111/bpa.13130

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