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Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma

[Image: see text] Anticoagulation therapy is a mainstay of the treatment of thrombotic disorders; however, conventional anticoagulants trade antithrombotic benefits for bleeding risk. Factor (f) XI deficiency, known as hemophilia C, rarely causes spontaneous bleeding, suggesting that fXI plays a lim...

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Detalles Bibliográficos
Autores principales: Modrzycka, Sylwia, Kołt, Sonia, Adams, Ty E., Potoczek, Stanisław, Huntington, James A., Kasperkiewicz, Paulina, Drąg, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041521/
https://www.ncbi.nlm.nih.gov/pubmed/36898159
http://dx.doi.org/10.1021/acs.jmedchem.2c00845