Dipeptide-Derived Alkynes as Potent and Selective Irreversible Inhibitors of Cysteine Cathepsins

[Image: see text] The potential of designing irreversible alkyne-based inhibitors of cysteine cathepsins by isoelectronic replacement in reversibly acting potent peptide nitriles was explored. The synthesis of the dipeptide alkynes was developed with special emphasis on stereochemically homogeneous...

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Detalles Bibliográficos
Autores principales: Behring, Lydia, Ruiz-Gómez, Gloria, Trapp, Christian, Morales, Maryann, Wodtke, Robert, Köckerling, Martin, Kopka, Klaus, Pisabarro, M. Teresa, Pietzsch, Jens, Löser, Reik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041539/
https://www.ncbi.nlm.nih.gov/pubmed/36867428
http://dx.doi.org/10.1021/acs.jmedchem.2c01360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041539/
https://www.ncbi.nlm.nih.gov/pubmed/36867428
http://dx.doi.org/10.1021/acs.jmedchem.2c01360

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