Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. The triggers for neurodegeneration in FTD with GRN (FTD-GRN) or C9orf72 (FTD-C9orf72) gene abnormalities are...

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Detalles Bibliográficos
Autores principales: Marian, Oana C., Teo, Jonathan D., Lee, Jun Yup, Song, Huitong, Kwok, John B., Landin-Romero, Ramon, Halliday, Glenda, Don, Anthony S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041703/
https://www.ncbi.nlm.nih.gov/pubmed/36967384
http://dx.doi.org/10.1186/s40478-023-01544-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041703/
https://www.ncbi.nlm.nih.gov/pubmed/36967384
http://dx.doi.org/10.1186/s40478-023-01544-7

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