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Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones with a range of affinities and concurrently carry...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042134/ https://www.ncbi.nlm.nih.gov/pubmed/36993964 http://dx.doi.org/10.3389/fimmu.2023.1080853 |