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Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones with a range of affinities and concurrently carry...

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Detalles Bibliográficos
Autores principales:	Garg, Amar K., Mitra, Tanmay, Schips, Marta, Bandyopadhyay, Arnab, Meyer-Hermann, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042134/ https://www.ncbi.nlm.nih.gov/pubmed/36993964 http://dx.doi.org/10.3389/fimmu.2023.1080853

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