SARS-CoV-2 M(pro) Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

[Image: see text] The main protease of SARS-CoV-2 (M(pro)) is the most promising drug target against coronaviruses due to its essential role in virus replication. With newly emerging variants there is a concern that mutations in M(pro) may alter the structural and functional properties of protease a...

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Detalles Bibliográficos
Autores principales: Chen, Sizhu Amelia, Arutyunova, Elena, Lu, Jimmy, Khan, Muhammad Bashir, Rut, Wioletta, Zmudzinski, Mikolaj, Shahbaz, Shima, Iyyathurai, Jegan, Moussa, Eman W., Turner, Zoe, Bai, Bing, Lamer, Tess, Nieman, James A., Vederas, John C., Julien, Olivier, Drag, Marcin, Elahi, Shokrollah, Young, Howard S., Lemieux, M. Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042146/
https://www.ncbi.nlm.nih.gov/pubmed/37122453
http://dx.doi.org/10.1021/acscentsci.3c00054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042146/
https://www.ncbi.nlm.nih.gov/pubmed/37122453
http://dx.doi.org/10.1021/acscentsci.3c00054

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