Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism

We show that TANGO2 in mammalian cells localizes predominantly to mitochondria and partially at mitochondria sites juxtaposed to lipid droplets (LDs) and the endoplasmic reticulum. HepG2 cells and fibroblasts of patients lacking TANGO2 exhibit enlarged LDs. Quantitative lipidomics revealed a marked...

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Detalles Bibliográficos
Autores principales: Lujan, Agustin Leonardo, Foresti, Ombretta, Sugden, Conor, Brouwers, Nathalie, Farre, Alex Mateo, Vignoli, Alessio, Azamian, Mahshid, Turner, Alicia, Wojnacki, Jose, Malhotra, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042531/
https://www.ncbi.nlm.nih.gov/pubmed/36961129
http://dx.doi.org/10.7554/eLife.85345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042531/
https://www.ncbi.nlm.nih.gov/pubmed/36961129
http://dx.doi.org/10.7554/eLife.85345

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