Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling

Acute lymphoblastic and myeloblastic leukemias (ALL and AML) have been known to modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. However, the molecular mechanisms driving these alterations remain poorly defined. Using mouse models of ALL and AML, here we show that leu...

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Detalles Bibliográficos
Autores principales: Feng, Xing, Sun, Ruifeng, Lee, Moonyoung, Chen, Xinyue, Guo, Shangqin, Geng, Huimin, Müschen, Marcus, Choi, Jungmin, Pereira, Joao Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042536/
https://www.ncbi.nlm.nih.gov/pubmed/36912771
http://dx.doi.org/10.7554/eLife.83533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042536/
https://www.ncbi.nlm.nih.gov/pubmed/36912771
http://dx.doi.org/10.7554/eLife.83533

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